RAC1 Genomic Alterations Drive Head and Neck Cancer Progression
Project Title(Chinese) :
RAC1基因變化在頭頸癌的病變
Principal Investigator(English) :
Prof Lui, Vivian Wai Yan
Principal Investigator(Chinese) :
Department :
School of Biomedical Sciences
Institution :
The Chinese University of Hong Kong
E-mail Address :
vlui002@cuhk.edu.hk
Tel :
Co - Investigator(s) :
Dr CHAN, Amy Bik-Wan
Dr Hong, Bo
Dr Lau, Chin-Wang
Dr Li, Ming
Dr Su, Richard Yuxiong
Panel :
Biology & Medicine
Subject Area :
Medicine, Dentistry & Health
Exercise Year :
2017 / 18
Fund Approved :
1,229,089
Project Status :
Completed
Completion Date :
31-8-2021
Project Objectives :
To compare RAC1 genomic alterations in Asian and US HNC patient tumors.
To determine the biological contributions of RAC1 mutations and amplification to HNC growth, invasion, anoikis, tumor-formation and metastasis.
a) To examine the in vitro and in vivo efficacies of PI3K inhibitors in RAC1-mutated HNC models, including RAC1 p.A159V and other RAC1 mutations.
b) To elucidate the mechanisms of PI3K/AKT hyperactivation conferred by the hotspot RAC1 p.A159V neomorphic mutation in HNC models.
Abstract as per original application (English/Chinese):
